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    • 专利摘要:
    The present innovation relates to cosmetic additives which have a complexing, dispersing and antimicrobial action. For the purpose of achieving a significant antimicrobial effect, as well as a very effective dispersion with simultaneous complexation of ions, the cosmetic additive comprises at least one linear alkali polyphosphate with a chain length of at least 3.
    公开号:AT12811U1
    申请号:TGM35/2012U
    申请日:2012-01-27
    公开日:2012-12-15
    发明作者:
    申请人:Bk Giulini Gmbh；
    IPC主号:
    专利说明:

    Austrian Patent Office AT12 811U1 2012-12-15
    Description: The present invention relates to cosmetic additives which have a complexing, dispersing and antimicrobial action.
    Phosphates are well known in the art, particularly in the food and detergent industry. The term phosphates refers to the salts or esters of phosphoric acid or the entire range of phosphate salts, of ortho- and di-bis to the polyphosphates and the esters of these acids. In the context of the present invention, linear polyphosphates having at least 3 phosphate groups are of interest. Up to the chain length 10 they are also called oligophosphates. Polyphosphates can also be characterized by the P205 content, Table 1 gives an overview.
    Table 1
    Chain length n Description P205 Content 1 Orthophosphate 43% 2 Diphosphate 53% 3 Triphosphates 58% 4-10 Oligophosphate 60-64% > 10 Polyphosphate 66-71% [0004] Due to their diverse properties, the phosphates are used in very different applications. The best-known application in addition to fertilizers and water treatment are detergents and cleaners. However, the detergent phosphates were banned in Germany just over 20 years ago to prevent the so-called eutrophication of the waters. In detergents, e.g. Geschirrspülmitteltabs, they are still largely allowed and are also used. The function that makes them suitable for these applications is their complexing effect on the dissolved calcium / magnesium ions, by means of which a water softening takes place and the dirt dispersion in the wash liquor.
    The use of phosphates in cosmetics has also been described in the prior art.
    According to DE 199 00 192 A1, phosphates, called diphosphate, triphosphate and polyphosphate, are to be added to ointments, creams, make-up, lipstick for the prevention and curing of fungal skin damage. A proof of effectiveness remains the DE 199 00192 A1 guilty.
    In DE 690 08 168 T2 an addition of phosphates to sunscreen containing titanium dioxide is described as a UVA filter. The phosphate ions added in an amount of 0.025 to 30% by weight associate spontaneously with the TiO 2 particles, i. a coating of phosphates forms on the surface of the TiO 2 particles, which prevents discoloration by the TiO 2. DE 690 08 168 T2 can be found in the same efficacy of all phosphates.
    A problem with the formulation of cosmetic agents, e.g. Sunscreen is the use of preservatives, such as parabens, often in a high amount, which can lead to allergic reactions in sensitive users. In addition, large amounts of parabens may be toxicologically questionable and therefore undesirable in cosmetic formulations.
    It has now surprisingly been found that linear Alkalipolyphosphate effect in such a cosmetic formulation, with or without coating of Ti02 particles with phosphates, both a significant antimicrobial effect, as well as a very effective dispersion with simultaneous complexation of ions.
    The present invention therefore solves the above problems by a complexing, dispersing and antimicrobial cosmetic additive comprising at least one linear alkali polyphosphate having a chain length of at least 3. Furthermore, the invention provides a mixture of at least one linear alkali polyphosphate with a chain length of at least 3 and a paraben as a preservative for cosmetics and sunscreens containing the cosmetic additive or preservative , Thus, a significantly reduced amount of paraben (e) for preservation is advantageously sufficient.
    The linear alkali polyphosphate preferably has a chain length of at least 4, more preferably of at least 5. Upwards, the chain length is not limited, in fact, alkali polyphosphates with chain lengths of 10, 15 to 50 phosphate groups have been found to be particularly effective. Even larger chain lengths show no better effectiveness. However, since the expense of synthesis and thus the cost increases with the chain length, alkali polyphosphates with chain lengths of up to 50, in particular up to 15 are preferred. By chain length is meant the mean chain length, which can be determined, for example, by 31P solution NMR.
    Preferably, the alkali polyphosphates are sodium and / or potassium polyphosphates. Particular preference is already given to using alkali polyphosphates approved as cosmetic ingredients, such as those available, for example, under the name Carephos N®, Carephos 322®, Carephos 244® and Carephos 188® from BK Giulini GmbH, Germany.
    Alkali polyphosphates can also be characterized by the P 2 O 5 content and the pH of their aqueous solution. According to the invention, the P 2 O 5 content is in the range from 58 to 71%, preferably in the range from 60 to 70% and in particular in the range from 62 to 70%. Preferably, the pH of an aqueous solution of the alkali polyphosphates according to the invention is in the range from 6.5 to 8.5, in particular from 7 to 7.5. The pH of the alkali polyphosphates is determined by the ratio of the alkali metal ions to the P205 content.
    The additive according to the invention is preferably used in an amount of 0.005 to 10 wt .-%, in particular from 0.001 to 2 wt .-%, based on the total formulation as an additive for dispersing, complexing and preservation of cosmetic and medical formulations.
    The preparation of the cosmetic and medical formulations is carried out in a conventional manner. In addition to the additive according to the invention, other additives and constituents which are known per se can and usually be contained; examples include dyes, pigments, active ingredients for cleaning, care, protection, fragrances, formulation and processing aids, etc. It is advantageous that the additive according to the invention can reduce the number of necessary ingredients, since it performs several functions. Thus it is possible to dispense with further complexing agents, dispersants and preservatives or to significantly reduce their amount.
    Formulations for cosmetics include O / W (oil-in-water) or W / O (water-in-oil) emulsions containing or consisting of water and a lipid component and the additive according to the invention.
    The lipid component is formed by one or more fat (s) and / wax (s). Suitable in principle are all known lipids, in particular animal fats, vegetable fats and oils, hydrogenated fats, synthetic triglycerides, solid and liquid waxes and wax-like compounds, fatty alcohols, sterols, saturated and unsaturated hydrocarbons and silicones. Particular preference is given to vegetable fats and oils, for example apricot kernel oil, argan oil, avocado oil, babassu oil, cottonseed oil, borage oil, candelilla wax, carnauba wax, cashew nut oil, peanut oil, safflower oil, oat oil, hazelnut oil, jojoba oil, cocoa butter, coconut milk, coconut oil, pumpkin seed oil, cow's milk fat, linseed oil, macadamia nut oil , Corn oil, almond oil, evening primrose oil, olive oil, palm kernel oil, palm oil, peach kernel oil, rapeseed oil, rice oil, castor oil, black currant, sesame oil, shea butter, soybean oil, sunflower oil, walnut oil, wheat germ oil, and animal fats such as butter, mink oil, and natural waxes such as 2 / 12 Austrian Patent Office AT 12 811 Ul 2012-12-15
    Beeswax and wool wax.
    Typically, a cosmetic formulation with the additive according to the invention also contains one or more of the following ingredients: anionic emulsifiers, eg sodium cetylstearyl sulfate or glycerol fatty acid compounds esterified with hydroxy acids such as lactic acid or citric acid or amino acids [0021] amphoteric emulsifiers, eg Betaines, lecithins and phospholipids and proteins and their hydrolyzates - neutral emulsifiers, e.g. Phosphoric acid alkyl esters, fatty acids, polyvalent esters
    Alcohols having free hydroxyl groups, polyglycerol esters and ethers, ethoxylated mono- and diglycerides, macrogold alcohol ethers, macrogol fatty acid esters, partial fatty acid esters of sugars, sorbitan fatty acid esters, macrogol-sorbitan fatty acid esters / polysorbates, and natural fatty mixtures with higher molecular weight alcohols, silicone derivatives - co-emulsifiers, quasi-emulsifiers or bodying agents , such as Fatty alcohols, gum arabic, natural lipids (waxes, triglycerides), semi-synthetic lipids (waxes, triglycerides, hydrogenated fats), synthetic waxes or fats, free fatty acids and fatty alcohols, terpenes, sterols, saturated and unsaturated hydrocarbons, and silicones - pigments and Dyes, such as, for example, titanium dioxide, aluminum silicates, pigment red, pigment violet, pigment yellow, iron oxides and hydroxides, barium sulfate, bentonite, chromium oxides, calcium carbonate, copper phthalocyanine, ultramarine, iron oxide, zinc oxide, manganese (III) ammonium diphosphate [0024] Fragrances such as essential oils, synthetic fragrances [0025] antioxidants [0026] complexing agents buffer substances and / or pH regulators [0028] active substances such as, for example, UV filters, in particular titanium dioxide or zinc oxide, and those organic filters coated with metallic cations, e.g. Iron to undesirable discolorations, in particular butylmethoxydibenzoylmethane - preservatives, in particular e.g. Parabens, but also benzoic acid, benzoic acid salts and esters, propionic acid and salts, salicylic acid and salts, sorbic acid and salts, o-phenylphenol, sodium o-phenylphenylate, chlorobutanol, 3-acetyl-6-methyl-2,4 (3H) -pyrandion and salts, 5-bromo-5-nitro-dioxane, 2-bromo-2-nitro-1,3-propanediol, triclosan, imidazolidinyl urea, poly (hexamethylene diguanide) hydrochloride, phenoxyethanol, quaternium 15, DMDM hydantoin, benzyl alcohol, pi-roctone olamine, 1,2-dibromo-2,4-dicyanobutane, o-cymen-5-ol, methylchloro- or methylisothiazolinone, chlorotacetamide, chlorhexidine, cetrimonium chloride or bromide, diazolidinyl urea, chlorphenesin , Sodium hydroxymethylaminoacetate.
    Particularly suitable is the additive according to the invention for formulations in which pigments are used, in particular formulations in which titanium dioxide is used, such. Sunscreen formulations. Furthermore, it is particularly suitable for formulations in which cations, such as iron, can lead to undesirable discoloration, especially formulations containing butylmethoxydibenzoylmethane, such as e.g. Sunscreen formulations. In addition, it is proven in cosmetic formulations that should contain the lowest possible amounts of preservatives, such as parabens.
    Advantageously, the cosmetic formulation may be provided in any desired consistency, from stable creams and ointments to less liquid lotions and milks to sprayable formulations. The additive according to the invention can be used particularly advantageously in sunscreens. These contain in a suitable basis at least one sunscreen active ingredient and the additive according to the invention. Typically, they contain other additives such as preservatives, binders and / or opacifiers, viscosity regulators, etc., most of which contain combinations thereof. As a basis are known per se emulsions, creams, ointments, gels, etc. into consideration. The additive according to the invention can be incorporated in particular into the aqueous phase and therefore particularly advantageous in emulsions. Therefore, these are preferred as both oil-in-water and water-in-oil emulsions.
    Furthermore, it was surprisingly found that Alkalipolyphosphate ideally complement in the preserving effect with parabens or act synergistically. Parabens are well known preservatives that are widely used. However, they are sometimes not well tolerated, at least for some people. According to the invention, the combination with alkali polyphosphates a smaller amount of parabens can be used without the preservation is impaired. Typical and suitable according to the invention parabens are, for example, methylparaben, propylparaben, Benzylparaben, Butalparaben, Ethylpara-ben, Hexamidinparaben, Isobutylparaben and Isodecylparaben, methyl and propylparaben are preferred.
    The invention will be explained with reference to the following examples, but without being limited to the specifically described embodiments. Unless otherwise stated or necessarily different from the context, percentages are based on weight, in case of doubt on the total weight of the mixture.
    The invention also relates to all combinations of preferred embodiments, insofar as they are not mutually exclusive. The indications " about " or " approx. " in conjunction with a numerical indication, means that at least 10% higher or lower values or 5% higher or lower values and in any case 1% higher or lower values are included.
    The dispersing action was demonstrated by the following experiments: EXAMPLE 1
    First, a model formulation containing an ingredient that forms agglomerate rate was provided. This recipe is given in Table 2. TABLE 2
    Phase Trade name INCI Name Quantity fgl A Water the. Water ad. 100 Glycerin Glycerin 3.00 Euxyl K 300 Preservation 0.50 B Keltrol CG-T Xanthan Gum 0.30 C Cetiol CC Dicaprylyl Carbonate 4.00 Cetiol Sensoft Propylheptyl Caprylate 4.50 Cosmedia DC Hydrogenated dimer Dilinelyl / Dimethyl Carbonate copolymer 1.00 Neo Heliopan OS Ethylhexyl Salicylate 7,50 Cosmedia Gel CC Dicaprylyl Carbonate (and) Stearalkonium Hectorite (and) Propylene Carbonate 2,00 4/12 Austrian Patent Office AT 12 811 Ul 2012-12-15 GB Emulgin VL 75 Lauryl Glucoside (and) Polygly- ceryl-2-dipolyhydroxy stearate (and) glycerin 3.00 Emulgade PL 68/50 Cetaryl Glucoside (and) Cetaryl Alcohol 2.50 E Titanium Dioxide E 171 Titanium Dioxide 15.00 EDTA EDTA 0 or 1.00 Sodium polyphosphate Sodium polyphosphate 0, 0 , 25 o. 1.00 For the preparation of the formulation phase B was dissolved in phase A until a homogeneous mass was obtained, which was then heated to a temperature of 75 to 80 ° C. Phase C was prepared by dissolving Cosmedia Gel CC in the rest of Phase C until a homogeneous phase was obtained. This was also heated to about 75 to 80 ° C and then the phase D was added and then the phase E stirred.
    The mixture of phase C, D, and E was added to the water phase and this mixture was stirred for 5 minutes at 70 rpm. This mixture was homogenized at 60 ° C with an Ultra Tur-rax stirrer at 11000 rpm and then stirred at 200 rpm until the temperature had dropped to room temperature.
    The dynamic viscosities of these formulations were determined after 24 hours at 25.4 ° C by means of the rotary viscometer Thermo Haake Roto Visko 1 at an approximate shear rate of 10 s'1 and are shown in Table 3. TABLE 3
    Emulsion Phase E Viscosity 1 15 g Titanium dioxide E 171 1.74 Pa s 2 15 g Titanium dioxide E 171 0.25 g Sodium polyphosphate 1.53 Pa s 3 15 g Titanium dioxide E 171 1.00 g Sodium polyphosphate 1.34 Pa s 4 15 g Titanium dioxide E171 1.00 g EDTA 1.64 Pa s The formulations thus prepared were stable after the centrifuge test. The addition of sodium polyphosphates resulted in a significantly improved distribution of the TiO 2 particles, which was detectable in the microscope and becomes clear at the lower viscosity.
    The results show that the addition of alkali polyphosphate compared to EDTA caused an improved dispersion of the inorganic pigments in cosmetic suspensions. EXAMPLE 2 The antimicrobial activity of the polyphosphates according to the invention was tested on a simple formulation given in Table 4. 5/12 Austrian Patent Office AT 12 811 Ul 2012-12-15 TABLE 4
    Phase Trade Name INCI Name Quantity ΓρΙ A Cutina KD 16 Glyceryl Stearate SE 12.00 Tegosoft HP Isocetyl Palmitate 10.00 B Methylparaben Methylparaben 0 0.0.18 Propylparaben Propylparaben 0 0.0.05 Carephos N Sodium Polyphosphate Oo. 1.00 Karion FP sorbitol 25.00 water water ad 100 Phases A and B were heated separately to 75 ° C. Phase B was added slowly to phase A with stirring. This mixture was emulsified at 400-500 rpm. At 60 ° C, the mixture was homogenized with an Ultra Turrax stirrer at 6000 rpm, then cooled to room temperature. Four test emulsions were prepared: Emulsion 1 Comparison without parabens and without polyphosphate pH: 7.96 Emulsion 2 Comparison with parabens and without polyphosphate pH: 8.22 Emulsion 3 according to the invention with polyphosphate and without Parabens pH: 7.53 Emulsion 4 according to the invention with parabens and with polyphosphate pH: 7.89 The determination of the antimicrobial activity was carried out with a preservation load test in accordance with the regulations of the European Pharmacopoeia, European Pharmacopoeia - Grundwerk 2008, 6 Edition, German Pharmacist Verlag Stuttgart. According to the European Pharmacopoeia, the following test organisms should be used: Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Aspergillus niger. Escherichia coli is a useful supplement. A topical formulation is sufficiently preserved if the criteria given in Table 5, at least criterion B, are met.
    TABLE 1: REQUIREMENTS FOR PREPARATIONS FOR TOPICAL APPLICATION log levels of germ count reduction
    Criterion 2 days 7 days 14 days 28 days Bacteria A 2 3 - No increase in bacterial count B - - 3 No increase in bacterial count Fungi A - - 2 No increase in bacterial count B - - 1 No increase in bacterial count In Tables 6 -10 are the numbers of colonies of the different emulsions tested, calculated from the measurements by the weighted arithmetic mean.
    TABLE 6: KEY FIGURES IN CFU / G FOR ESCHERICHIA COLI
    Emulsi on before addition days after addition 0 2 7 14 21 28 1 <102 7.5 106 106 9.5106 1.2 106 9.5106 4.5 106 2 <102 4.3 106 2.9 105 102 &lt; 10 10 &lt; 10 3 &lt; 102 1.4 107 9 106 1.2 107 8.5 106 1.4 107 3.7 106 4 <102 2.2 105 102 &lt; 10 &lt; 10 &lt; 10 &lt; 10 6/12 Austrian Patent Office AT 12 811 Ul 2012-12-15
    TABLE 7: KEY FIGURES IN CFU / G FOR PSEUDOMONAS AERUGINOSA
    Emulsi on before addition Days after addition 0 2 7 14 21 28 1 &lt; 102 1 107 1.6 107 2,1 107 1,6 107 3 107 1,8 107 2 &lt; 102 6 106 2,6 105 4,4 105 2 105 3 105 9,5 105 3 &lt; 102 4,9 106 1.6 107 3 107 3.3 107 4.7 107 2.4 107 4 &lt; 102 7 105 &lt; 102 &lt; 10 &lt; 10 &lt; 10 &lt; 10
    TABLE 8: KEY FIGURES IN CFU / G FOR STAPHYLOCOCCUS AUREUS
    Emulsions before addition Days after addition 0 2 7 14 21 28 1 <102 8 106 7.5 105 7.5 105 2.5 104 7.5 102 6.7 101 2 &lt; 102 2.5 106 7.1 105 2 104 5.5 103 <102 102 3 <102 7.5 106 1.2 106 1 105 2 103 <102 9.5 101 4 <102 8.5 106 106 4.6 104 6 102 &lt; 10 &lt; 10 &lt; 10
    TABLE 9: KEY FIGURES IN CFU / G FOR ASPERGILLUS NIGER
    Emulsions before addition days after addition 0 2 7 14 21 28 1 &lt; 102 1.7 103 2 103 2 103 4.2 103 3.9 103 1.5 104 2 <102 9.5 102 9.5 102 6 102 102 7,1 101 1,9 101 3 <102 1, 7 103 1.1 103 1.5 102 1.1 102 4.5 101 7.1 101 4 <102 1.4 103 2.5 102 102 &lt; 10 &lt; 10 &lt; 10
    TABLE 10: KEY FIGURES IN CFU / G FOR CANDIDA ALBICANS
    Emulsions before use days after use 0 2 7 14 21 28 1 <102 4,3 104 2,4 105 7,1 105 3,8 105 4,5 105 5 105 2 <102 105 1,2 105 1.6 105 6.2 104 7.6 104 6.6 104 3 <102 8.6 104 3.7 104 3.5 102 102 <102 <10 4 <102 1.9 105 1 It is found that the effect of the combination of parabens with polyphosphate in emulsion 4 with respect to all microorganisms shows an efficacy which satisfies criterion A of the European Pharmacopoeia. For the fungi, the number of germs was reduced by at least two log levels after 14 days and there was no increase in the number of germs thereafter. After 2 days, the bacterial count was reduced by at least two log levels, after 7 days the number of germs was reduced by three log levels, and thereafter no increase in the number of germs occurred. The recommended efficacy according to the European Pharmacopoeia is given by the combination of polyphosphate and parabens, the polyphosphates support the preservation of parabens positively.
    In the emulsion 3 with polyphosphate but without parabens, there was a reduction in the number of bacteria of Staphylococcus aureus, Aspergillus niger and Candida albicans. However, the number of bacteria of Staphylococcus aureus was also in the comparative emulsion 1 without 7/12 Austrian Patent Office AT 12 811 Ul 2012-12-15
    Parabens and reduced without polyphosphate. In the case of Aspergillus niger and Candida albicans emulsion 3 without parabens, but with polyphosphate, resulted in a reduction in the number of germs. In contrast, in comparison emulsion 1 without parabens and without polyphosphate, no reduction in the number of bacteria was observed. Polyphosphate thus inhibits the growth / proliferation of Aspergillus niger and Candida albicans.
    In the comparative emulsion 2 with parabens but without polyphosphate the efficacy of the European Pharmacopoeia was not met. In the case of mushrooms, in order to fulfill criterion B, the germ count would have to be reduced by one log level after 14 days. This was not the case. In the case of the bacteria, criterion A was not met by E. coli and Staphylococcus aureus, criterion B only. Since no criterion was met in Pseudomonas aeruginosa, the efficacy was not sufficient for the bacteria in the European Pharmacopeia. So it would be necessary an increased amount of parabens. EXAMPLE 3 For the detection of a complexing effect by phosphates, iron ions are used which have been used in practice e.g. through pipelines, mixers or raw materials in recipes can be introduced. The basic formulation used was the formulation of a sunscreen formulation with butylmethoxydibenzoylmethane. This UVA filter forms an intense red complex even with traces of iron. The complexing effect was tested on the following formulation: TABLE 11
    Phase Trade name INCI Name Quantity [gl A Water the. Water ad. 100 Glycerol Glycerol 3.00 Euxyl K 300 Preservative 0.50 B Keltrol CG-T Xanthan Gum 0.30 Veegum Magnesium Aluminum Silicate 2.00 C Cetiol CC Dicaprylyl Carbonate 4.00 Cetiol Sensoft Propylheptyl Caprylate 4.50 Cosmedia DC Hydrogenated dimer Dilinelyl / Dimethyl Carbonate Copolymer 1.00 Neo Heliopane 303 Octocrylene 10.00 Neo Heliopane OS Ethylhexyl Salicylate 7.50 Neo Heliopane 357 Butyl Methoxy-dibenzoylmethane 5.00 Cosmedia Gel CC Dicaprylyl Carbonate (and) Ste-Aralkonium Hectorite (and) Propylene Lene Carbonate 2.00 D Emulgin VL 75 Lauryl Glucoside (and) Polyglyceryl-2-dipolyhydroxy stearate (and) Glycerol 3.00 Emulgade PL 68/50 Cetaryl Glucoside (and) Cetaryl Alcohol 2.50 E Eusolex T-AVO Titanium Dioxide, Silica 7.50 The water phase of the formulation was prepared by dissolving Phase B in Phase A until a homogeneous phase was obtained. This was brought to a temperature of about 75-80 ° C. Phase C was prepared by dissolving Cosmedia Gel CC in the rest of Phase C until a homogeneous phase was obtained. This was also heated to about 75-80 ° C and then phase D was added first and then stirred phase E. The mixture of phase C, D and E was added to the water phase and this mixture was stirred for 5 minutes at 750 rpm. Thereafter, the formulation was cooled down to room temperature at 200 rpm, wherein at about 60 ° C for one minute at 11000 rpm was homogenized using an Ultra-Turrax.
    The following additives were added to the formulation described: 0.01 g of ferric chloride hexahydrate
    0.01 g of ferric chloride hexahydrate and 0.045 g of Carephos N
    0.01 g of ferric chloride hexahydrate and 0.09 g of Carephos N
    0.01 g of ferric chloride hexahydrate and 0.09 g of disodium EDTA
    0.01% ferric chloride hexahydrate and 0.045% Utanit AF
    0.01% iron II l chloride hexahydrate and 0.09% Utanit AF
    0.01% Ferric chloride hexahydrate and 0.09% Phoskadent pyro The respective proportion of iron-l chloride hexahydrate, Carephos N (linear alkali polyphosphate), Disodium EDTA, Utanit AF (acid Diphosphate for comparison) and Phoskadent Pyro (alkaline diphosphate for comparison) is incorporated into the water phase and subtracted from the water content.
    The evaluation was carried out by means of a color measurement. The color status of the formulations was recorded after 6 weeks with the Minolta chroma meter CR 300. Numerical values are obtained during the measurement, whereby an objective comparison of the individual formulations is possible. In the measurement, three numbers are determined: L, a and b. The L value describes the light-dark values, where &quot; 0 &quot; for an ideal black and &quot; 100 &quot; stands for an ideal white. The a value describes the red-green values and the b value is based on the yellow-blue values. The a and b values have different signs, since the present CIE-Lab system assumes that no color can be both reddish and greenish at the same time or at the same time yellowish and bluish. Therefore, -a stands for green, + a for red, -b for blue and + b for yellow. In the measurement, the differences of the L, a and b values become the "white standard". with the values L: 98.19; a: -0.01 and b: +1.48. The following results were obtained: Formulation L: -21.82; a: +1.07; b: +0.78 formulation + 0.01% ferric chloride hexahydrate L: -24.81; a: +5.18; b: + 3.99 formulation + 0.01% ferric chloride hexahydrate + 0.045% Carephos N L: -24.58; a: + 3.63; b: + 2.82 [0069] formulation + 0.01% ferric chloride hexahydrate + 0.09% Carephos N L: -23.34; a: +3.37; b: +2.54 formulation + 0.01% ferric chloride hexahydrate + 0.09% disodium EDTA: L: -26.44; a: +5.18; b: + 4.10 formulation + 0.01% ferric chloride hexahydrate + 0.045% utanite AF L: -23.46; a: + 3.95; b: +3.17 formulation + 0.01% ferric chloride hexahydrate + 0.09% utanite AF L: -23.67; a: +3.22; b: + 2.30 [0073] formulation + 0.01% ferric chloride hexahydrate + 0.09% Phoscadent Pyro L: -25.41; a: +4.44; b: +3.28 Since red complexes are formed in this case, the a-values are especially important
    权利要求:
    Claims (16)
    [1]
    Austrian Patent Office AT 12 811 Ul 2012-12-15 and shown in FIG. The higher the a value, the worse the complexing effect. For comparison, the value of the formula with 0.01% ferric chloride hexahydrate is used. The best complexing performance was achieved by the acidic phosphate Utanit AF. However, the formulations with Utanit AF did not remain sufficiently stable. Although the stability of the formulation could be achieved by adding the alkaline phosphate Phoskadent Pyro, the complexing effect decreased considerably. A similarly good complexing performance as with the formulations with Utanit AF was achieved by the phosphate Carephos N. The formulations with Carephos N also remained stable. Disodium EDTA did not achieve a complexing effect in this case. Surprisingly, therefore, only Alkalipolyphosphate in cosmetic emulsions complex metal ions well, with good dispersion and preservation. Claims 1. A cosmetic additive with complexing, dispersing and antimicrobial activity, characterized in that it comprises at least one linear alkali polyphosphate having a chain length of at least 3.
    [2]
    2. Cosmetic additive according to claim 1, characterized in that the linear alkali polyphosphate has a chain length of at least 4, preferably a chain length of 4 to 50, in particular from 8 to 15.
    [3]
    3. Cosmetic additive according to claim 1 or 2, characterized in that the linear alkali polyphosphate is a sodium and / or potassium polyphosphate, in particular a sodium polyphosphate.
    [4]
    4. Cosmetic additive according to at least one of claims 1 to 3, characterized in that it is contained in a cosmetic preparation in an amount of 0.005 to 10 wt .-%, preferably from 0.001 to 2 wt .-%, based on the total preparation ,
    [5]
    5. Cosmetic additive according to at least one of claims 1 to 4, characterized in that at least one paraben, in particular a methylparaben or Propylpara-ben is included.
    [6]
    6. Cosmetic preparation, characterized in that it contains a cosmetic additive according to one of claims 1 to 5.
    [7]
    7. A preparation according to claim 6, characterized in that it is an emulsion, suspension, solution, cream, ointment, gel, stick or spray.
    [8]
    8. Preparation according to claim 6 or 7, characterized in that it is a sunscreen containing the additive, at least one sunscreen active ingredient and optionally additives in a suitable basis.
    [9]
    9. Preparation according to claim 6, 7 or 8, characterized in that additives, in particular dyes, pigments, active ingredients for cleaning, active ingredients for care, active ingredients for protection, fragrances, formulation auxiliaries and / or processing aids are contained.
    [10]
    10. Use of linear Alkalipolyphosphaten having a chain length of at least 3 as a cosmetic additive with complexing, dispersing and anti-microbial effect in cosmetic preparations.
    [11]
    11. Use according to claim 10, characterized in that the linear alkali polyphosphate has a chain length of at least 4, preferably a chain length of 4 to 50, in particular from 8 to 15.
    [12]
    12. Use according to claim 10 or 11, characterized in that the linear alkali polyphosphate is a sodium and / or potassium polyphosphate, in particular a sodium umpolyphosphat. 10/12 Austrian Patent Office AT 12 811 Ul 2012-12-15
    [13]
    13. Use according to any one of claims 10 to 12, characterized in that an amount of 0.005 to 10 wt .-%, preferably from 0.001 to 2 wt .-%, based on the total preparation is included.
    [14]
    14. Use according to any one of claims 10 to 13, characterized in that at least one paraben, in particular a methylparaben or propylparaben is included.
    [15]
    15. A method for complexing, dispersing and preserving cosmetic preparations, characterized in that a cosmetic additive according to any one of claims 1 to 3 is added to a cosmetic preparation.
    [16]
    16. The method according to claim 15, characterized in that at least one paraben, in particular a methylparaben or propylparaben, is added. For this 1 sheet drawings 11/12
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    EA027948B1|2017-09-29|
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    WO2013107624A2|2013-07-25|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE201220000469|DE202012000469U1|2012-01-19|2012-01-19|Cosmetic additive containing alkali polyphosphates|
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